Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q96BI1
UPID:
S22AI_HUMAN
Alternative names:
Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein; Efflux transporter-like protein; Imprinted multi-membrane-spanning polyspecific transporter-related protein 1; Organic cation transporter-like protein 2; Solute carrier family 22 member 1-like; Tumor-suppressing STF cDNA 5 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein; p45-Beckwith-Wiedemann region 1 A
Alternative UPACC:
Q96BI1; O14906; O43562; O60485; O60680; Q7LDS5; Q7LGF7
Background:
Solute carrier family 22 member 18, also known as Efflux transporter-like protein and Organic cation transporter-like protein 2, plays a crucial role in the transport of organic cations through a proton efflux antiport mechanism. It is implicated in the transport of vital compounds like chloroquine and quinidine-related compounds in the kidney, showcasing its significance in cellular transport processes.
Therapeutic significance:
Given its involvement in lung cancer and embryonal rhabdomyosarcoma, understanding the role of Solute carrier family 22 member 18 could pave the way for novel therapeutic strategies. Its potential in modulating drug transport and resistance mechanisms in these malignancies highlights its therapeutic significance.