Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q96CA5
UPID:
BIRC7_HUMAN
Alternative names:
Kidney inhibitor of apoptosis protein; Livin; Melanoma inhibitor of apoptosis protein; RING finger protein 50; RING-type E3 ubiquitin transferase BIRC7
Alternative UPACC:
Q96CA5; Q9BQV0; Q9H2A8; Q9HAP7
Background:
Baculoviral IAP repeat-containing protein 7 (BIRC7), also known as Livin, plays a pivotal role in apoptosis regulation, cell proliferation, and cell cycle control. It exhibits both proapoptotic and anti-apoptotic activities, mediated through the inhibition of caspases and its E3 ubiquitin-protein ligase activity. BIRC7's ability to ubiquitinate DIABLO/SMAC, targeting it for degradation, underscores its significance in promoting cell survival.
Therapeutic significance:
Understanding the role of Baculoviral IAP repeat-containing protein 7 could open doors to potential therapeutic strategies. Its involvement in apoptosis and cell cycle control makes it a promising target for cancer therapy, offering avenues for the development of novel treatments that manipulate cell death pathways.