Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q96CM3
UPID:
RUSD4_HUMAN
Alternative names:
RNA pseudouridylate synthase domain-containing protein 4
Alternative UPACC:
Q96CM3; E9PML2; Q96K56
Background:
Pseudouridylate synthase RPUSD4, mitochondrial, also known as RNA pseudouridylate synthase domain-containing protein 4, plays a crucial role in mitochondrial RNA processing. It catalyzes the conversion of uridine to pseudouridine in mitochondrial RNA, impacting the assembly of mitochondrial ribosomes and intra-mitochondrial translation. This enzyme is pivotal for the modification of 16S mitochondrial ribosomal RNA and mitochondrial tRNA(Phe), enhancing the functionality of mitochondrial ribosomes.
Therapeutic significance:
Understanding the role of Pseudouridylate synthase RPUSD4, mitochondrial could open doors to potential therapeutic strategies.