Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q96CW1
UPID:
AP2M1_HUMAN
Alternative names:
AP-2 mu chain; Adaptin-mu2; Adaptor protein complex AP-2 subunit mu; Adaptor-related protein complex 2 subunit mu; Clathrin assembly protein complex 2 mu medium chain; Clathrin coat assembly protein AP50; Clathrin coat-associated protein AP50; HA2 50 kDa subunit; Plasma membrane adaptor AP-2 50 kDa protein
Alternative UPACC:
Q96CW1; A6NE12; D3DNT1; P20172; P53679
Background:
The AP-2 complex subunit mu, known by various names such as Adaptin-mu2 and Clathrin assembly protein complex 2 mu medium chain, plays a pivotal role in the adaptor protein complex 2 (AP-2). This complex is integral to protein transport via vesicles in different membrane traffic pathways, including clathrin-dependent endocytosis, where it aids in cargo selection and vesicle formation. AP-2 is crucial for receptor-mediated endocytosis and synaptic vesicle membrane recycling, recognizing specific motifs within transmembrane cargo molecules.
Therapeutic significance:
Given its involvement in Intellectual developmental disorder, autosomal dominant 60, with seizures, understanding the role of AP-2 complex subunit mu could open doors to potential therapeutic strategies. Its function in synaptic vesicle recycling and endocytosis underscores its potential as a target in neurological disorders.