Focused On-demand Library for Cytochrome c oxidase assembly protein COX14

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.

Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.

The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.

Our high-tech, dedicated method is applied to construct targeted libraries.

Fig. 1. The sreening workflow of Receptor.AI

Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.

Our library distinguishes itself through several key aspects:

The Receptor.AI platform integrates all available data about the target protein, including past experiments, literature data, known ligands, structural information and more. This consolidated approach maximises the probability of prioritising highly relevant compounds.
The platform uses sophisticated molecular simulations to identify possible binding sites so that the compounds in the focused library are suitable for discovering allosteric inhibitors and the binders for cryptic pockets.
The platform integrates over 50 highly customisable AI models, which are thoroughly tested and validated on a multitude of commercial drug discovery programs and research projects. It is designed to be efficient, reliable and accurate. All this power is utilised when producing the focused libraries.
In addition to producing the focused libraries, Receptor.AI provides services and end-to-end solutions at every stage of preclinical drug discovery. The pricing model is success-based, which reduces your risks and leverages the mutual benefits of the project's success.

partner

Reaxense

upacc

Q96I36

UPID:

COX14_HUMAN

Alternative names:

Alternative UPACC:

Q96I36; B2R5G6

Background:

Cytochrome c oxidase assembly protein COX14 is a core component of the MITRAC complex, crucial for mitochondrial function. It plays a pivotal role in the assembly of cytochrome c oxidase, a key enzyme in the mitochondrial respiratory chain. This process is essential for the coordination of early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1, highlighting its significance in cellular energy production.

Therapeutic significance:

Given its critical role in mitochondrial function, COX14 is linked to Mitochondrial complex IV deficiency, nuclear type 10, a severe disorder characterized by neurological, respiratory, and metabolic abnormalities leading to early infant death. Understanding the role of Cytochrome c oxidase assembly protein COX14 could open doors to potential therapeutic strategies for mitochondrial disorders.