Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q96JI7
UPID:
SPTCS_HUMAN
Alternative names:
Colorectal carcinoma-associated protein; Spastic paraplegia 11 protein
Alternative UPACC:
Q96JI7; A8KAX9; B9EK60; F5H3N6; Q4VC11; Q58G86; Q69YG6; Q6NW01; Q8N270; Q8TBU9; Q9H734
Background:
Spatacsin, also known as Colorectal carcinoma-associated protein and Spastic paraplegia 11 protein, plays a crucial role in neurite plasticity. It maintains cytoskeleton stability and regulates synaptic vesicle transport, essential for proper neuronal function.
Therapeutic significance:
Spatacsin's involvement in diseases such as Spastic paraplegia 11, Amyotrophic lateral sclerosis 5, and Charcot-Marie-Tooth disease, highlights its potential as a target for therapeutic strategies. Understanding its role could lead to breakthroughs in treating these neurodegenerative disorders.