Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q96P09
UPID:
BIRC8_HUMAN
Alternative names:
Inhibitor of apoptosis-like protein 2; Testis-specific inhibitor of apoptosis
Alternative UPACC:
Q96P09; Q6IPY1; Q96RW5
Background:
Baculoviral IAP repeat-containing protein 8, also known as Inhibitor of apoptosis-like protein 2 and Testis-specific inhibitor of apoptosis, plays a crucial role in cellular survival mechanisms. Its primary function is to protect against apoptosis mediated by BAX, a pro-apoptotic protein. This protection is vital for cell longevity and preventing premature cell death.
Therapeutic significance:
Understanding the role of Baculoviral IAP repeat-containing protein 8 could open doors to potential therapeutic strategies. Its ability to inhibit apoptosis positions it as a key target for developing treatments aimed at diseases where cell survival is compromised.