Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q96PM5
UPID:
ZN363_HUMAN
Alternative names:
Androgen receptor N-terminal-interacting protein; CH-rich-interacting match with PLAG1; E3 ubiquitin-protein ligase Pirh2; RING finger protein 199; RING-type E3 ubiquitin transferase RCHY1; Zinc finger protein 363; p53-induced RING-H2 protein
Alternative UPACC:
Q96PM5; B3KRG3; C7E541; C7E542; C7E543; D3YRV2; E7EMC8; E7ETW5; J3KPI0; Q2KN33; Q59GN7; Q86X26; Q96PR5
Background:
RING finger and CHY zinc finger domain-containing protein 1, known as RCHY1, plays a pivotal role in cellular processes through its E3 ubiquitin-protein ligase activity. It targets key proteins such as p53/TP53, TP73, and HDAC1 for ubiquitination, influencing cell cycle regulation and DNA damage response. RCHY1's involvement in the ribosome-associated quality control pathway highlights its critical function in managing protein synthesis and degradation.
Therapeutic significance:
Understanding the role of RING finger and CHY zinc finger domain-containing protein 1 could open doors to potential therapeutic strategies. Its ability to regulate protein stability and degradation pathways presents a unique opportunity for targeting diseases where these processes are dysregulated.