Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q96RU2
UPID:
UBP28_HUMAN
Alternative names:
Deubiquitinating enzyme 28; Ubiquitin thioesterase 28; Ubiquitin-specific-processing protease 28
Alternative UPACC:
Q96RU2; B0YJC0; B0YJC1; Q6NZX9; Q9P213
Background:
Ubiquitin carboxyl-terminal hydrolase 28, also known as Deubiquitinating enzyme 28, plays a crucial role in DNA damage response and MYC proto-oncogene stability. It specifically deubiquitinates proteins in the DNA damage pathway, such as CLSPN, and is pivotal in the G2 DNA damage checkpoint. This enzyme uniquely interacts with isoform 1 of FBXW7 in the nucleoplasm to prevent MYC degradation, while not affecting isoform 4, allowing selective MYC degradation in the nucleolus.
Therapeutic significance:
Understanding the role of Ubiquitin carboxyl-terminal hydrolase 28 could open doors to potential therapeutic strategies.