Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q96SF7
UPID:
TBX15_HUMAN
Alternative names:
T-box transcription factor TBX14
Alternative UPACC:
Q96SF7; Q08E76; Q5JT54; Q5T9S7
Background:
T-box transcription factor TBX15, alternatively known as TBX14, plays a crucial role in skeletal development, particularly in the limbs, vertebral column, and head. It regulates the balance between mesenchymal precursor cells and chondrocytes, essential for proper bone and cartilage formation.
Therapeutic significance:
Cousin syndrome, characterized by unique skeletal abnormalities and potential intellectual impairment, is directly linked to variants in the TBX15 gene. Understanding the role of T-box transcription factor TBX15 could open doors to potential therapeutic strategies for this condition.