Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9BT22
UPID:
ALG1_HUMAN
Alternative names:
Asparagine-linked glycosylation protein 1 homolog; Beta-1,4-mannosyltransferase; GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase; GDP-mannose-dolichol diphosphochitobiose mannosyltransferase; Mannosyltransferase-1
Alternative UPACC:
Q9BT22; B4DP08; Q6UVZ9; Q8N5Y4; Q9P2Y2
Background:
Chitobiosyldiphosphodolichol beta-mannosyltransferase, also known as Asparagine-linked glycosylation protein 1 homolog, plays a pivotal role in the biosynthesis of glycoproteins. It catalyzes the addition of the first mannose moieties, essential for proper N-linked glycosylation, a process critical for protein folding and stability.
Therapeutic significance:
This protein's malfunction is linked to Congenital disorder of glycosylation 1K, a condition with a wide range of clinical features including nervous system defects and immunodeficiency. Targeting the protein's function could lead to novel treatments for this multisystem disorder.