Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9BUD6
UPID:
SPON2_HUMAN
Alternative names:
Differentially expressed in cancerous and non-cancerous lung cells 1; Mindin
Alternative UPACC:
Q9BUD6; D3DVN9; Q4W5N4; Q9ULW1
Background:
Spondin-2, also known as Mindin and differentially expressed in cancerous and non-cancerous lung cells 1, is a pivotal cell adhesion protein. It plays a crucial role in promoting adhesion and outgrowth of hippocampal embryonic neurons. Beyond its structural functions, Spondin-2 directly binds to bacteria and their components, acting as an opsonin for macrophage phagocytosis of bacteria. This positions it as an essential molecule in initiating the innate immune response and as a unique pattern-recognition molecule in the extracellular matrix for microbial pathogens.
Therapeutic significance:
Understanding the role of Spondin-2 could open doors to potential therapeutic strategies.