Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9BVS5
UPID:
TR61B_HUMAN
Alternative names:
mRNA methyladenosine-N(1)-methyltransferase
Alternative UPACC:
Q9BVS5; Q9H0Q9; Q9NWS7
Background:
The tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial, also known as mRNA methyladenosine-N(1)-methyltransferase, plays a crucial role in mitochondrial function. It catalyzes the formation of N(1)-methyladenine in various tRNAs within the mitochondrion, impacting tRNA(Leu), tRNA(Lys), and tRNA(Ser). This enzyme also modifies mitochondrial 16S ribosomal RNA, essential for mitoribosomal structure and function, and acts on MT-ND5 mRNA, affecting mitochondrial translation.
Therapeutic significance:
Understanding the role of tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial could open doors to potential therapeutic strategies.