Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9BWP8
UPID:
COL11_HUMAN
Alternative names:
Collectin kidney protein 1
Alternative UPACC:
Q9BWP8; A1IGE4; A1IGE5; A1IGE6; A7VJJ2; A7VJJ3; A7VJJ4; A7VJJ5; B2R9M5; B4E1G0; J3KQY9; Q5CZ85; Q7Z6N1
Background:
Collectin-11, also known as Collectin kidney protein 1, is a calcium-dependent lectin involved in innate immunity, apoptosis, and embryogenesis. It recognizes high mannose oligosaccharides and certain fucosylated glycans, playing a crucial role in the body's defense mechanism by binding non-self sugars on microorganisms. Additionally, it participates in apoptosis by interacting with DNA on apoptotic cells and aids in embryonic development by guiding cell migration.
Therapeutic significance:
Collectin-11's involvement in 3MC syndrome 2, a disorder characterized by facial dysmorphism, craniosynostosis, and various anomalies, highlights its potential as a target for therapeutic intervention. Understanding the role of Collectin-11 could open doors to potential therapeutic strategies.