Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9BWT3
UPID:
PAPOG_HUMAN
Alternative names:
Neo-poly(A) polymerase; Polynucleotide adenylyltransferase gamma; SRP RNA 3'-adenylating enzyme; Signal recognition particle RNA-adenylating enzyme
Alternative UPACC:
Q9BWT3; B2RBH4; Q59G05; Q969N1; Q9H8L2; Q9HAD0
Background:
Poly(A) polymerase gamma, also known as Neo-poly(A) polymerase, plays a crucial role in the post-transcriptional adenylation of mRNA precursors and small RNAs, including SRP RNA and ribosomal 5S RNA. This enzyme's activity is pivotal for RNA stability and function, influencing the efficiency of mRNA translation and the cellular response to stress.
Therapeutic significance:
Understanding the role of Poly(A) polymerase gamma could open doors to potential therapeutic strategies. Its involvement in RNA processing and stability positions it as a key player in cellular homeostasis and disease mechanisms.