Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9BWT7
UPID:
CAR10_HUMAN
Alternative names:
CARD-containing MAGUK protein 3
Alternative UPACC:
Q9BWT7; Q14CQ8; Q5TFG6; Q8NC81; Q9UGR5; Q9UGR6; Q9Y3H0
Background:
Caspase recruitment domain-containing protein 10, also known as CARD-containing MAGUK protein 3, plays a pivotal role in immune response regulation. It acts as a scaffold protein, crucial for the activation of NF-kappa-B via BCL10 or EGFR, signaling pathways that are essential for immune cell activation and inflammatory responses.
Therapeutic significance:
The protein is linked to Immunodeficiency 89 and autoimmunity, a disorder marked by recurrent infections, allergies, microcytic anemia, and Crohn disease. This association highlights its potential as a target for therapeutic intervention in immune-related disorders.