Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9BWX5
UPID:
GATA5_HUMAN
Alternative names:
GATA-binding factor 5
Alternative UPACC:
Q9BWX5; D9ZGF7; Q17RE2; Q86VU4
Background:
Transcription factor GATA-5, also known as GATA-binding factor 5, plays a pivotal role in cardiovascular development. It is essential for the transcriptional programs that drive smooth muscle cell diversity and is known to bind to the CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer. This protein's involvement in the intricate processes of heart development underscores its significance in cardiovascular biology.
Therapeutic significance:
GATA-5 is linked to Congenital heart defects, multiple types, 5 (CHTD5), a disorder characterized by a spectrum of congenital heart abnormalities. The disease's association with variants affecting the GATA-5 gene highlights its potential as a target for therapeutic intervention. Understanding the role of Transcription factor GATA-5 could open doors to potential therapeutic strategies, offering hope for individuals affected by congenital heart defects.