Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9BZV3
UPID:
IMPG2_HUMAN
Alternative names:
Interphotoreceptor matrix proteoglycan of 200 kDa; Sialoprotein associated with cones and rods proteoglycan
Alternative UPACC:
Q9BZV3; A8MWT5; Q9UKD4; Q9UKK5
Background:
Interphotoreceptor matrix proteoglycan 2, also known as a 200 kDa sialoprotein associated with cones and rods, plays a crucial role in the organization of the interphotoreceptor matrix. It binds to chondroitin sulfate and hyaluronan, contributing to the maturation and maintenance of photoreceptor outer segments. This protein's interaction with heparin highlights its significance in the retinal structure.
Therapeutic significance:
Given its involvement in Retinitis pigmentosa 56 and Macular dystrophy, vitelliform, 5, understanding the role of Interphotoreceptor matrix proteoglycan 2 could open doors to potential therapeutic strategies. These diseases, characterized by loss of vision and retinal degeneration, underscore the protein's clinical relevance.