Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9H2H0
UPID:
CXXC4_HUMAN
Alternative names:
Inhibition of the Dvl and axin complex protein
Alternative UPACC:
Q9H2H0
Background:
CXXC-type zinc finger protein 4, alternatively known as Inhibition of the Dvl and axin complex protein, plays a crucial role in the Wnt signaling pathway by negatively regulating it through interaction with DVL1. This protein has a preference for binding to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides, showcasing specificity towards hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG.
Therapeutic significance:
Understanding the role of CXXC-type zinc finger protein 4 could open doors to potential therapeutic strategies.