Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9H422
UPID:
HIPK3_HUMAN
Alternative names:
Androgen receptor-interacting nuclear protein kinase; Fas-interacting serine/threonine-protein kinase; Homolog of protein kinase YAK1
Alternative UPACC:
Q9H422; O14632; Q2PBG4; Q2PBG5; Q92632; Q9HAS2
Background:
Homeodomain-interacting protein kinase 3 (HIPK3) serves as a serine/threonine-protein kinase with pivotal roles in transcription regulation, apoptosis, and steroidogenic gene expression. It is known for phosphorylating key proteins such as JUN and RUNX2, and for its involvement in enhancing androgen receptor-mediated transcription. HIPK3's ability to phosphorylate FADD suggests a role in negatively regulating apoptosis, while its interaction with NR5A1 upon cAMP signaling pathway stimulation leads to increased steroidogenic gene expression.
Therapeutic significance:
Understanding the role of Homeodomain-interacting protein kinase 3 could open doors to potential therapeutic strategies.