Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9H5V7
UPID:
IKZF5_HUMAN
Alternative names:
Ikaros family zinc finger protein 5
Alternative UPACC:
Q9H5V7; B3KVH7; D3DRE7; Q9H2T0
Background:
Zinc finger protein Pegasus, also known as Ikaros family zinc finger protein 5, plays a crucial role in transcriptional repression, binding the core DNA consensus sequence to influence gene expression. Its involvement in megakaryocyte differentiation highlights its importance in the hematopoietic system.
Therapeutic significance:
The protein's association with Thrombocytopenia 7, a disorder characterized by a reduced platelet count leading to bleeding risks, underscores its potential as a target for therapeutic intervention. Understanding the role of Zinc finger protein Pegasus could open doors to potential therapeutic strategies.