Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9H6L5
UPID:
RETR1_HUMAN
Alternative names:
Reticulophagy receptor 1
Alternative UPACC:
Q9H6L5; Q69YN8; Q9H6K6; Q9H764; Q9NXM8
Background:
Reticulophagy regulator 1, also known as Reticulophagy receptor 1, plays a pivotal role in cellular homeostasis. It is an ER-anchored autophagy regulator, facilitating ER delivery into lysosomes through autophagosomes. This protein is crucial for membrane remodeling, ER scission, and collagen quality control. Additionally, it supports the long-term survival of nociceptive and autonomic ganglion neurons.
Therapeutic significance:
Reticulophagy regulator 1 is linked to Neuropathy, hereditary sensory and autonomic, 2B (HSAN2B), a disorder characterized by sensory and autonomic abnormalities. Understanding the role of Reticulophagy regulator 1 could open doors to potential therapeutic strategies for HSAN2B, offering hope for patients suffering from this debilitating condition.