Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9H867
UPID:
MT21D_HUMAN
Alternative names:
Methyltransferase-like protein 21D; VCP lysine methyltransferase; Valosin-containing protein lysine methyltransferase
Alternative UPACC:
Q9H867; B7ZLA3; B7ZLA4; Q2M2X3; Q86T12
Background:
Protein N-lysine methyltransferase METTL21D, also known as Methyltransferase-like protein 21D, VCP lysine methyltransferase, and Valosin-containing protein lysine methyltransferase, plays a crucial role in post-translational modifications. It specifically trimethylates 'Lys-315' of VCP/p97, a modification that may modulate VCP ATPase activity.
Therapeutic significance:
Understanding the role of Protein N-lysine methyltransferase METTL21D could open doors to potential therapeutic strategies.