Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9HAQ2
UPID:
KIF9_HUMAN
Alternative names:
-
Alternative UPACC:
Q9HAQ2; Q86Z28; Q9H8A4
Background:
Kinesin-like protein KIF9 plays a pivotal role in male reproductive health, being essential for normal male fertility and ensuring the progressive motility of spermatozoa. This protein's unique function highlights its importance in the complex process of sperm motility, a critical factor for successful fertilization.
Therapeutic significance:
Understanding the role of Kinesin-like protein KIF9 could open doors to potential therapeutic strategies. Its critical involvement in sperm motility and male fertility positions it as a key target for addressing male infertility issues, offering hope for novel fertility treatments.