Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9HAW0
UPID:
BRF2_HUMAN
Alternative names:
B-related factor 2; hBRFU
Alternative UPACC:
Q9HAW0; B2RD62; B4DFZ6; D3DSW6; Q9H2Y3; Q9H3B3; Q9NUY6
Background:
The Transcription factor IIIB 50 kDa subunit, also known as B-related factor 2 or hBRFU, plays a pivotal role in RNA polymerase III transcription. It is an essential activator for genes with promoter elements upstream of initiation sites, influencing gene expression under both normal and oxidative stress conditions. Its ability to down-regulate target genes during oxidative stress and protect cells against apoptosis underscores its significance in cellular defense mechanisms.
Therapeutic significance:
Understanding the role of Transcription factor IIIB 50 kDa subunit could open doors to potential therapeutic strategies.