Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9HC07
UPID:
TM165_HUMAN
Alternative names:
Transmembrane protein PT27; Transmembrane protein TPARL
Alternative UPACC:
Q9HC07; A8K3P8; B4DHW1; Q9BTN9; Q9NZ34
Background:
Transmembrane protein 165, also known as Transmembrane protein PT27 or TPARL, plays a crucial role in cellular processes. It is believed to function as a calcium/proton transporter, which is vital for maintaining calcium levels and lysosomal pH homeostasis. This protein's activity is essential for protein glycosylation, a process critical for protein function and stability.
Therapeutic significance:
The protein is linked to Congenital disorder of glycosylation 2K, a disease characterized by psychomotor and growth retardation, among other symptoms. Understanding the role of Transmembrane protein 165 could open doors to potential therapeutic strategies for this disorder, highlighting its importance in medical research.