Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9HCP0
UPID:
KC1G1_HUMAN
Alternative names:
-
Alternative UPACC:
Q9HCP0; Q5JPH1; Q96AE9; Q9HCP1
Background:
Casein kinase I isoform gamma-1, encoded by the gene with accession number Q9HCP0, is a serine/threonine-protein kinase. It is known for its role in phosphorylating a wide array of proteins, showcasing its versatility in cellular processes. This kinase is a key player in the Wnt signaling pathway and is crucial for regulating synaptic transmission mediated by glutamate, highlighting its importance in neural communication.
Therapeutic significance:
Understanding the role of Casein kinase I isoform gamma-1 could open doors to potential therapeutic strategies. Its involvement in critical signaling pathways and neural communication underscores its potential as a target for drug discovery, aiming to modulate its activity for therapeutic benefits.