Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9NR22
UPID:
ANM8_HUMAN
Alternative names:
Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4
Alternative UPACC:
Q9NR22; B2RDP0; Q8TBJ8
Background:
Protein arginine N-methyltransferase 8 (PRMT8), also known as Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4, is a key enzyme in the post-translational modification of proteins. It specializes in the methylation of arginine residues, a process critical for the modulation of protein function and signaling. PRMT8's activity includes the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), impacting proteins such as NIFK, myelin basic protein, and histones H4, H2A, and the H2A/H2B dimer.
Therapeutic significance:
Understanding the role of Protein arginine N-methyltransferase 8 could open doors to potential therapeutic strategies.