Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9NR45
UPID:
SIAS_HUMAN
Alternative names:
N-acetylneuraminate synthase; N-acetylneuraminate-9-phosphate synthase; N-acetylneuraminic acid phosphate synthase; N-acetylneuraminic acid synthase
Alternative UPACC:
Q9NR45; B2RE98; Q8WUV9; Q9BWS6; Q9NVD4
Background:
Sialic acid synthase, known by alternative names such as N-acetylneuraminate synthase and N-acetylneuraminic acid synthase, plays a pivotal role in the biosynthesis of sialic acids. These acids are crucial components of glycoproteins and glycolipids, serving as key elements in cellular recognition processes. The enzyme's ability to produce N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) underscores its significance in cellular physiology.
Therapeutic significance:
The enzyme's link to Spondyloepimetaphyseal dysplasia, Genevieve type, a disorder marked by developmental delays and skeletal dysplasia, highlights its therapeutic potential. Understanding the role of Sialic acid synthase could open doors to potential therapeutic strategies for treating this genetic condition.