Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9NVJ2
UPID:
ARL8B_HUMAN
Alternative names:
ADP-ribosylation factor-like protein 10C; Novel small G protein indispensable for equal chromosome segregation 1
Alternative UPACC:
Q9NVJ2; B4DI85
Background:
ADP-ribosylation factor-like protein 8B (ARL8B) is a small GTPase pivotal in lysosomal positioning and function. It transitions between active GTP-bound and inactive GDP-bound states, engaging with effector proteins to regulate lysosomal transport, fusion, and positioning. ARL8B's specific localization to lysosomal membranes facilitates anterograde lysosomal motility, essential for nutrient sensing, NK cell-mediated cytotoxicity, and antigen presentation. It plays a crucial role in endosome to lysosome trafficking, impacting antigen presentation, microbial killing, and plasma membrane repair during infections.
Therapeutic significance:
Understanding the role of ADP-ribosylation factor-like protein 8B could open doors to potential therapeutic strategies.