Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9NVR5
UPID:
KTU_HUMAN
Alternative names:
Dynein assembly factor 2, axonemal
Alternative UPACC:
Q9NVR5; B9WS54; C0JAP7; Q86TR1; Q86TY8; Q969Z5
Background:
Protein kintoun, also known as Dynein assembly factor 2, axonemal, plays a pivotal role in the motility of cilia and flagella. It is essential for the cytoplasmic pre-assembly of axonemal dyneins, crucial components for the movement in ciliary and flagellar structures.
Therapeutic significance:
Mutations in the gene encoding Protein kintoun are linked to Primary Ciliary Dyskinesia, a disorder marked by chronic respiratory infections and reduced fertility. Understanding the role of Protein kintoun could open doors to potential therapeutic strategies for this condition.