Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9NY33
UPID:
DPP3_HUMAN
Alternative names:
Dipeptidyl aminopeptidase III; Dipeptidyl arylamidase III; Dipeptidyl peptidase III; Enkephalinase B
Alternative UPACC:
Q9NY33; B2RDB5; B4DLX4; F5H8L6; O95748; Q969H2; Q9BV67; Q9HAL6
Background:
Dipeptidyl peptidase 3, known by alternative names such as Dipeptidyl aminopeptidase III and Enkephalinase B, plays a crucial role in the degradation of bioactive peptides, including angiotensin and enkephalins. Its ability to cleave specific substrates like Arg-Arg-beta-naphthylamide highlights its specificity and importance in biochemical pathways.
Therapeutic significance:
Understanding the role of Dipeptidyl peptidase 3 could open doors to potential therapeutic strategies. Its involvement in cleaving and degrading peptides pivotal for physiological processes underscores its potential as a target for drug discovery, aiming to modulate its activity for therapeutic benefits.