Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9NYL2
UPID:
M3K20_HUMAN
Alternative names:
Human cervical cancer suppressor gene 4 protein; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; Mitogen-activated protein kinase kinase kinase MLT; Mixed lineage kinase 7; Mixed lineage kinase-related kinase; Sterile alpha motif- and leucine zipper-containing kinase AZK
Alternative UPACC:
Q9NYL2; B3KPG2; Q53SX1; Q580W8; Q59GY5; Q86YW8; Q9HCC4; Q9HCC5; Q9HDD2; Q9NYE9
Background:
Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) is a pivotal stress-activated component in protein kinase signal transduction cascades, crucial for programmed cell death in response to various stresses including ribosomal stress and ionizing radiation. It activates JNK and MAP kinase p38 pathways through phosphorylation, playing a key role in cellular responses to adrenergic stimulation and cardiac stress.
Therapeutic significance:
MAP3K20's involvement in split-foot malformation with mesoaxial polydactyly and centronuclear myopathy highlights its potential as a therapeutic target. Understanding the role of MAP3K20 could open doors to potential therapeutic strategies for these genetic disorders.