Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9P0M2
UPID:
AKA7G_HUMAN
Alternative names:
A-kinase anchor protein 18 kDa; Protein kinase A-anchoring protein 7 isoform gamma
Alternative UPACC:
Q9P0M2; B4DUC3; Q9HCZ8
Background:
A-kinase anchor protein 7 isoform gamma, also known as A-kinase anchor protein 18 kDa or Protein kinase A-anchoring protein 7 isoform gamma, plays a crucial role in targeting cAMP-dependent protein kinase (PKA) to cellular membranes or cytoskeletal structures. This protein's interaction with the cellular membrane reduces epithelial sodium channel (ENaC) activity, while its cytoplasmic form may regulate ENaC channel feedback inhibition by intracellular sodium.
Therapeutic significance:
Understanding the role of A-kinase anchor protein 7 isoform gamma could open doors to potential therapeutic strategies, particularly in diseases where ENaC activity is implicated.