Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9UGP5
UPID:
DPOLL_HUMAN
Alternative names:
DNA polymerase beta-2; DNA polymerase kappa
Alternative UPACC:
Q9UGP5; D3DR76; Q5JQP5; Q6NUM2; Q9BTN8; Q9HA10; Q9HB35
Background:
DNA polymerase lambda, also known as DNA polymerase beta-2 or kappa, plays a pivotal role in DNA repair pathways, including base excision repair (BER) and DNA double-strand break repair through non-homologous end joining and homologous recombination. It exhibits both template-dependent and template-independent DNA polymerase activities, alongside a 5'-deoxyribose-5-phosphate lyase activity, crucial for maintaining genomic stability.
Therapeutic significance:
Understanding the role of DNA polymerase lambda could open doors to potential therapeutic strategies. Its involvement in key DNA repair mechanisms makes it a promising target for enhancing the efficacy of cancer treatments that induce DNA damage, potentially leading to innovative approaches in cancer therapy.