Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9UGP8
UPID:
SEC63_HUMAN
Alternative names:
-
Alternative UPACC:
Q9UGP8; O95380; Q5THN4; Q86VS9; Q8IWL0; Q9NTE0
Background:
The Translocation protein SEC63 homolog plays a crucial role in protein translocation across the endoplasmic reticulum (ER), facilitating the transport of precursor polypeptides. It aids in the recognition of precursors with short and apolar signal peptides, working alongside SEC62 and HSPA5/BiP to enable the entry of small presecretory proteins into the SEC61 translocon complex.
Therapeutic significance:
Given its essential function in PKD1/Polycystin-1 biogenesis and trafficking, critical for primary cilia function, the Translocation protein SEC63 homolog is directly linked to Polycystic liver disease 2. Understanding the role of this protein could open doors to potential therapeutic strategies for treating this hepatobiliary disease and its renal manifestations.