Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9UHD9
UPID:
UBQL2_HUMAN
Alternative names:
Chap1; DSK2 homolog; Protein linking IAP with cytoskeleton 2; Ubiquitin-like product Chap1/Dsk2
Alternative UPACC:
Q9UHD9; O94798; Q5D027; Q9H3W6; Q9HAZ4
Background:
Ubiquilin-2, known by alternative names such as Chap1 and DSK2 homolog, plays a pivotal role in protein degradation pathways including the ubiquitin-proteasome system (UPS), autophagy, and the ER-associated protein degradation (ERAD) pathway. It targets misfolded or accumulated proteins for degradation, mediates autophagosome-lysosome fusion, and is involved in the maturation of the autophagy-related protein LC3.
Therapeutic significance:
Ubiquilin-2's involvement in Amyotrophic lateral sclerosis 15, a neurodegenerative disorder, underscores its therapeutic significance. Understanding the role of Ubiquilin-2 could lead to novel therapeutic strategies for treating this fatal paralysis, highlighting the importance of research into its functions and disease associations.