Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9UHR6
UPID:
ZNHI2_HUMAN
Alternative names:
Protein FON
Alternative UPACC:
Q9UHR6; Q3SY14; Q8IUV0
Background:
Zinc finger HIT domain-containing protein 2, also known as Protein FON, plays a crucial role in cellular processes by mediating interactions between the R2TP/Prefoldin-like complex and U5 small nuclear ribonucleoprotein. It is essential for the assembly of key components within the U5 snRNP complex, influencing its composition and functionality.
Therapeutic significance:
Understanding the role of Zinc finger HIT domain-containing protein 2 could open doors to potential therapeutic strategies.