Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9UHX3
UPID:
AGRE2_HUMAN
Alternative names:
EGF-like module receptor 2; EGF-like module-containing mucin-like hormone receptor-like 2
Alternative UPACC:
Q9UHX3; B4DQ96; E7ESD7; E9PBR1; E9PEL6; E9PFQ5; E9PG91; Q8NG96; Q9Y4B1
Background:
Adhesion G protein-coupled receptor E2, also known as EGF-like module receptor 2, plays a pivotal role in cell attachment by binding to the chondroitin sulfate of glycosaminoglycan chains. It is instrumental in granulocyte chemotaxis, degranulation, and adhesion, and in macrophages, it triggers the release of inflammatory cytokines, including IL8 and TNF. This receptor is a key regulator of mast cell degranulation.
Therapeutic significance:
Linked to Vibratory urticaria, a disorder characterized by hives and systemic manifestations in response to dermal vibration, Adhesion G protein-coupled receptor E2's involvement suggests potential therapeutic targets. Understanding its role could lead to novel treatments for this and related inflammatory conditions.