Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9UKV8
UPID:
AGO2_HUMAN
Alternative names:
Argonaute RISC catalytic component 2; Eukaryotic translation initiation factor 2C 2; PAZ Piwi domain protein; Protein slicer
Alternative UPACC:
Q9UKV8; Q8TCZ5; Q8WV58; Q96ID1
Background:
Protein argonaute-2, also known as Argonaute RISC catalytic component 2, plays a pivotal role in RNA-mediated gene silencing, including RNA interference (RNAi) and microRNA (miRNA) pathways. It is essential for the RNA-induced silencing complex (RISC), guiding RISC to target mRNAs for silencing or degradation. This protein's ability to interact with small RNAs and its involvement in translational repression and mRNA cleavage underscore its critical function in gene regulation.
Therapeutic significance:
The association of Protein argonaute-2 with Lessel-Kreienkamp syndrome, a disorder marked by developmental delays and behavioral disorders, highlights its potential as a therapeutic target. Understanding the role of Protein argonaute-2 could open doors to potential therapeutic strategies for treating this syndrome and possibly other related conditions.