Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9UL45
UPID:
BL1S6_HUMAN
Alternative names:
Pallid protein homolog; Pallidin; Syntaxin 13-interacting protein
Alternative UPACC:
Q9UL45
Background:
Biogenesis of lysosome-related organelles complex 1 subunit 6, also known as Pallidin, plays a crucial role in the formation of lysosome-related organelles. It is a component of the BLOC-1 complex, essential for the biogenesis of platelet dense granules and melanosomes. This protein is involved in vesicle trafficking, particularly in docking and fusion processes, and is critical for neurite extension.
Therapeutic significance:
Pallidin's association with Hermansky-Pudlak syndrome 9, a disorder characterized by oculocutaneous albinism, bleeding, and lysosomal storage defects, highlights its potential as a therapeutic target. Understanding Pallidin's role could open doors to novel treatments for this syndrome.