Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9UNQ2
UPID:
DIM1_HUMAN
Alternative names:
DIM1 dimethyladenosine transferase 1 homolog; DIM1 dimethyladenosine transferase 1-like; Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase; Probable 18S rRNA dimethylase; Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
Alternative UPACC:
Q9UNQ2; O76025; Q9BU77; Q9UES1
Background:
Probable dimethyladenosine transferase plays a pivotal role in ribosomal RNA processing, specifically targeting two adenosines within the 18S rRNA component of the 40S ribosomal subunit. This enzymatic activity is crucial for the structural integrity and function of ribosomes, which are essential for protein synthesis in all living cells. The protein is also a key player in the assembly of the small subunit processome, facilitating RNA folding, modifications, and cleavage.
Therapeutic significance:
Understanding the role of Probable dimethyladenosine transferase could open doors to potential therapeutic strategies. Its central function in ribosome biogenesis and RNA processing highlights its potential as a target for interventions in diseases where these processes are dysregulated.