Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9Y230
UPID:
RUVB2_HUMAN
Alternative names:
48 kDa TATA box-binding protein-interacting protein; 51 kDa erythrocyte cytosolic protein; INO80 complex subunit J; Repressing pontin 52; TIP49b; TIP60-associated protein 54-beta
Alternative UPACC:
Q9Y230; B3KQ59; E7ETE5; Q6FIB9; Q6PK27; Q9Y361
Background:
RuvB-like 2, known by alternative names such as TIP49b and INO80 complex subunit J, plays a pivotal role in cellular processes. It exhibits single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase activities, essential for DNA repair and transcriptional regulation. As a component of the NuA4 histone acetyltransferase complex, it is involved in acetylation of nucleosomal histones H4 and H2A, influencing gene expression and DNA repair.
Therapeutic significance:
Understanding the role of RuvB-like 2 could open doors to potential therapeutic strategies.