Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9Y286
UPID:
SIGL7_HUMAN
Alternative names:
Adhesion inhibitory receptor molecule 1; CDw328; D-siglec; QA79 membrane protein; p75
Alternative UPACC:
Q9Y286; Q9NZQ1; Q9UJ86; Q9UJ87; Q9Y502
Background:
Sialic acid-binding Ig-like lectin 7, known by alternative names such as Adhesion inhibitory receptor molecule 1 and CDw328, plays a crucial role in mediating sialic-acid dependent binding to cells. It has a preference for alpha-2,3- and alpha-2,6-linked sialic acid and interacts with disialogangliosides. This protein is involved in the immune response by acting as an inhibitory receptor, mediating inhibition of natural killer cells' cytotoxicity, and playing a role in hemopoiesis.
Therapeutic significance:
Understanding the role of Sialic acid-binding Ig-like lectin 7 could open doors to potential therapeutic strategies.