Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9Y3I0
UPID:
RTCB_HUMAN
Alternative names:
3'-phosphate/5'-hydroxy nucleic acid ligase
Alternative UPACC:
Q9Y3I0; B2R6A8; Q6IAI0; Q9BWL4; Q9NTH1; Q9P037; Q9P0J3
Background:
RNA-splicing ligase RtcB homolog, also known as 3'-phosphate/5'-hydroxy nucleic acid ligase, plays a pivotal role in RNA processing. It acts as a catalytic subunit within the tRNA-splicing ligase complex, joining spliced tRNA halves into mature tRNAs. This process incorporates the precursor-derived splice junction phosphate into the mature tRNA, showcasing its essential function in RNA ligase activity with broad substrate specificity.
Therapeutic significance:
Understanding the role of RNA-splicing ligase RtcB homolog could open doors to potential therapeutic strategies. Its critical function in RNA processing highlights its potential as a target for interventions in diseases where RNA splicing and processing are compromised.