Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9Y448
UPID:
SKAP_HUMAN
Alternative names:
Kinetochore-localized astrin-binding protein; Kinetochore-localized astrin/SPAG5-binding protein; TRAF4-associated factor 1
Alternative UPACC:
Q9Y448; B4DXA7; Q147U5; Q32Q57; Q5ISJ0; Q6P2S5; Q6PJM0; Q86XB4
Background:
The Small kinetochore-associated protein, also known as Kinetochore-localized astrin-binding protein, plays a pivotal role in chromosome segregation during cell division. It ensures accurate chromosome alignment and segregation, critical for maintaining genetic stability. This protein is a key component of the mitotic spindle, essential for the metaphase-to-anaphase transition, and is involved in the dynamics of microtubule plus-ends and kinetochore oscillations during mitosis.
Therapeutic significance:
Linked to Roifman-Chitayat syndrome, a condition characterized by developmental delay, neurologic features, and immunodeficiency, the Small kinetochore-associated protein's study could lead to novel therapeutic approaches for this and potentially other related genetic disorders.