Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9Y462
UPID:
ZN711_HUMAN
Alternative names:
Zinc finger protein 6
Alternative UPACC:
Q9Y462; B4DSV4; Q6NX42; Q9Y4J6
Background:
Zinc finger protein 711, also known as Zinc finger protein 6, plays a pivotal role in brain development. It functions as a transcription regulator, essential for neuron development by activating the expression of genes such as KDM5C. This activation is facilitated through the recruitment of PHF8 histone demethylase, highlighting its significance in transcriptional regulation.
Therapeutic significance:
Zinc finger protein 711 is linked to Intellectual developmental disorder, X-linked 97, a condition marked by below-average intellectual functioning and adaptive behavior impairments. Understanding the role of Zinc finger protein 711 could open doors to potential therapeutic strategies for this disorder.