Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9Y4F4
UPID:
TGRM1_HUMAN
Alternative names:
Crescerin-1; Protein FAM179B
Alternative UPACC:
Q9Y4F4; Q68D66; Q6PG27
Background:
TOG array regulator of axonemal microtubules protein 1, also known as Crescerin-1 or Protein FAM179B, plays a pivotal role in ciliogenesis. It ensures the proper acetylation and polyglutamylation of ciliary microtubules, crucial for cilium length regulation. Its interaction with microtubules and promotion of microtubule polymerization, particularly through its HEAT repeat domains in the TOG region 2 and 4, underscores its significance in cellular structure and function.
Therapeutic significance:
Linked to Joubert syndrome 37, a disorder characterized by cerebellar ataxia, oculomotor apraxia, and other symptoms, TOG array regulator of axonemal microtubules protein 1's study could lead to novel therapeutic approaches. Understanding its role in ciliogenesis and microtubule dynamics offers a promising avenue for addressing this autosomal recessive disease.