Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9Y5X3
UPID:
SNX5_HUMAN
Alternative names:
-
Alternative UPACC:
Q9Y5X3; B7ZKN3; D3DW26; Q52LC4; Q7KZN0; Q9BWP0
Background:
Sorting nexin-5 plays a pivotal role in intracellular trafficking, interacting with specific phosphatidylinositol-containing membranes. It is a key component of the retromer SNX-BAR subcomplex, facilitating the retrograde transport of cargo proteins from endosomes to the trans-Golgi network and participating in cargo protein recycling. This protein is crucial for the retrograde transport of the lysosomal enzyme receptor IGF2R and may serve as a link between endosomal transport vesicles and dynactin. Additionally, it is involved in the internalization and endosomal sorting of EGFR post-EGF stimulation, as well as in E-cadherin sorting and degradation.
Therapeutic significance:
Understanding the role of Sorting nexin-5 could open doors to potential therapeutic strategies.