Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9Y617
UPID:
SERC_HUMAN
Alternative names:
Phosphohydroxythreonine aminotransferase
Alternative UPACC:
Q9Y617; Q5T7G5; Q5T7G6; Q96AW2; Q9BQ12
Background:
Phosphoserine aminotransferase, also known as Phosphohydroxythreonine aminotransferase, plays a crucial role in amino acid metabolism by catalyzing the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. This enzyme's activity is pivotal for the biosynthesis of serine and glycine, essential components for various biological processes.
Therapeutic significance:
Phosphoserine aminotransferase deficiency and Neu-Laxova syndrome 2 are severe diseases linked to mutations in the gene encoding this enzyme, highlighting its critical role in human health. Understanding the enzyme's function could pave the way for innovative treatments for these and potentially other related disorders.